Research Mission
We use Nuclear Magnetic Resonance (NMR) methods to investigate complex biological mechanisms, including protein folding and misfolding, and chaperone mediated proteostasis. By combining NMR with fluorescence-based techniques, mass spectrometry and electron microscopy we aim to develop new approaches that visualize these events across the microscopic to the macroscopic scales.
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The group has local access to state of the art NMR spectrometers (solution 400, 600, 800 MHz, solid-state 600 MHz) and many other world-class facilities (950 MHz, electron microscopy) hosted in the nearby Francis-Crick Institute.
NMR
Excited states
Studying lowly-populated, biologically important, protein states that are not accessible by other methods is a keen interest for the lab.
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Chaperones
The Hsp40-Hsp70 cycle
Of particular interest is the study of the mechanisms that Hsp40s use to cooperate with Hsp70, a crucial component for cell integrity
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Methods
Integrative biology
We aim to develop integrative/computational approaches that combine experimental data with AI models to study complex systems
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